February 12 | 2015

Flupharm goes to school

Flupharm scientist Oliver Szolar presents the project to European science teachers

This week, 22 science teachers from all over Europe came to EMBL Grenoble for a two-day course co-organised by Flupharm and the European Learning Laboratory for the Life Sciences (ELLS) on how structural biology can aid drug discovery.

November 19 | 2014


Structural insight into cap-snatching and RNA synthesis by influenza polymerase

Authors |Stefan Reich, Delphine Guilligay, Alexander Pflug, Hélène Malet, Imre Berger, Thibaut Crépin, Darren Hart, Thomas Lunardi, Max Nanao, Rob W. H. Ruigrok & Stephen Cusack

November 19 | 2014



Structure of influenza A polymerase bound to the viral RNA promoter


Video: Structure of complete flu polymerase

Authors | Pflug, Guilligay, Reich & Cusack

August 12 | 2014


Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I

Authors |M. Weber, H. Sediri, U. Felgenhauer, I. Binzen, S, Bänfer, R. Jacob, L. Brunotte, A. Garcia-Sastre, J.L. Schmid-Burgk, T. Schmidt, V. Hornung, G. Kochs, M. Schwemmle, H.D. Klenk, and F. Weber

June 4 | 2014


PB2 Mutations D701N and S714R Promote Adaptation of an Influenza H5N1 Virus to a Mammalian Host

Interaction of amino acids 701 and 714 with the NLS in the C-terminal 524 domain of PB2 (modelling by Mikhail Matrosovich)


Authors | Czudai-Matwich V, Otte A, Matrosovich M, Gabriel G, Klenk HD