European Molecular Biology Laboratory

uropean Molecular Biology Laboratory, Grenoble Outstation

EMBL is an international organization financed by 20 countries. It aims to strengthen basic research in the molecular life sciences in Europe by pursuing five missions:

°       to conduct basic molecular biology research,
°       to provide essential services to scientists across Europe,
°       to provide high level training to scientists,
°       to develop new instrumentation for biological research,
°       and to transfer technology.

EMBL Grenoble, one of 5 EMBL sites, is embedded in a unique environment for integrated structural biology in Grenoble, the Partnership for Structural Biology.

The Partnership for Structural Biology provides state-of-the-art platforms for all aspects of structural biology. EMBL Grenoble is closely involved in instrumentation and user support on the synchrotron beamlines of the ESRF (European Synchrotron Radiation Facility), and has brought important innovations to nano-volume protein crystallization and protein expression technologies.

Its major research focus is on the structural biology of proteins, complexes and processes involved in transcription, RNA metabolism and host-pathogen interactions. EMBL-GR has access to the Chemical Screening Facility at EMBL-HD where high-throughput screens for cap-binding and endonuclease inhibitors are performed.

www.embl.org
www.embl.fr
www.esrf.eu


STEPHAN CUSACK | PhD
(1976)

Current position: Head of Grenoble Outstation of EMBL, Senior scientists and group leader in structural biology of protein-RNA complexes and viral proteins.

Main technique: X-ray crystallography using synchrotron radiation.

Research focus: Structure-based understanding of influenza virus replication and gene-expression, host adaption and anti-viral drug design. Large experience in co-ordinating or participating in large EU projects (SPINE, SPINE2-Complexes, INSTRUCT, PCube). Coordinator of the FP6 STREP FLUPOL (2007-2010). More than 140 peer-reviewed publications.

 

DARREN HART | PhD (1996)

Current position: Team Leader in High Throughput Protein Technologies.

Main technique: Darren established the high-throughput screening technique ESPRIT for finding soluble domains in difficult-to-express proteins, which was very successfully applied to influenza virus polymerase subunits.

Research focus: Methods development to produce complexes of several drug targets for functional assays and structural studies (influenza polymerase subunits, human kinases and histone deacetylases). Participant in EU projects (SPINE, SPINE2, 3D Repertoire, SOUTH & FLUPOL projects).