Heinrich-Pette-Institut für Virologie

Heinrich-Pette-Institut für Virologie, Influenza Pathogenese

The Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology (HPI) is a non-profit, independent research foundation belonging to the Leibniz Association (WGL). Federal funding is administered by the Federal Health Ministry and state funding by the Science and Research Authority in Hamburg.

The research at HPI focuses on basic virology and immunology of viruses such as influenza, herpes and retroviruses. Major accomplishments are the elucidation of molecular mechanisms involved in the pathogenesis, interspecies transmission, and host adaptation of influenza viruses, and the development of new antiviral strategies.

HPI has state-of-the art equipment (e.g. cryo-electron microscopy, tomography, BIACORE, FPLC-HPLC, MALDI-TOF, BSL-2 and BSL-3 facilities as well as BSL-2 and BSL-3 animal rooms), and has been a partner in numerous EU projects (e.g. DISMAL, ACTIVEP53, MutP53, Oxnorm, Mutant p53 in cancer).




Current position: Independent junior group leader (Emmy Noether programme, DFG) in influenza pathogenesis at the HPI.

Main technique: Influenza virology/molecular genetics and animal models in BSL-2 and BSL-3 settings. First discoveries that influenza virus polymerase is an important determinant of host adaptation and its interaction with the cellular import machinery resulting in altered host range.

Research focus: Understanding how influenza viruses cross species barriers and adapt to new species, with special emphasis on the interplay between the viral polymerase (viral determinant of host adaptation) and the cellular import machinery (cellular determinant of host adaptation). Principal investigator in projects of the DFG (SFB-595, Emmy-Noether) and the BMBF (FluResearchNet) and former association in EU projects (FluINNATE and FluPOL).